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Differences in the uptake of modified low density lipoproteins by tissue cultured endothelial cells.

Authors
  • Gaffney, J
  • West, D
  • Arnold, F
  • Sattar, A
  • Kumar, S
Type
Published Article
Journal
Journal of cell science
Publication Date
Nov 01, 1985
Volume
79
Pages
317–325
Identifiers
PMID: 3833867
Source
Medline
License
Unknown

Abstract

Acetylated low density lipoprotein (Ac-LDL) is taken up by bovine aortic and adrenal capillary cells but not by brain capillary cells. This indicates that the uptake of Ac-LDL is not a feature of all types of endothelial cell. A quantitative examination of lipoprotein uptake by flow cytometry showed cells in G2M took up 45% more Ac-LDL than those in G1S. Compared with confluent cultures, sub-confluent bovine aortic cells took up three times as much LDL but Ac-LDL uptake was increased by only 34%. This indicates that the Ac-LDL receptor is not down-regulated to the same extent as that for LDL.

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