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Differences in the uptake of modified low density lipoproteins by tissue cultured endothelial cells.

Authors
Type
Published Article
Journal
Journal of cell science
Publication Date
Volume
79
Pages
317–325
Identifiers
PMID: 3833867
Source
Medline
License
Unknown

Abstract

Acetylated low density lipoprotein (Ac-LDL) is taken up by bovine aortic and adrenal capillary cells but not by brain capillary cells. This indicates that the uptake of Ac-LDL is not a feature of all types of endothelial cell. A quantitative examination of lipoprotein uptake by flow cytometry showed cells in G2M took up 45% more Ac-LDL than those in G1S. Compared with confluent cultures, sub-confluent bovine aortic cells took up three times as much LDL but Ac-LDL uptake was increased by only 34%. This indicates that the Ac-LDL receptor is not down-regulated to the same extent as that for LDL.

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