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Differences in Lung and Lobe Volumes between Supine and Standing Positions Scanned with Conventional and Newly Developed 320-Detector-Row Upright CT: Intra-Individual Comparison

Authors
  • Yamada, Yoshitake
  • Yamada, Minoru
  • Yokoyama, Yoichi
  • Tanabe, Akiko
  • Matsuoka, Shiho
  • Niijima, Yuki
  • Narita, Keiichi
  • Nakahara, Takehiro
  • Murata, Mitsuru
  • Fukunaga, Koichi
  • Chubachi, Shotaro
  • Jinzaki, Masahiro
Type
Published Article
Journal
Respiration
Publisher
S. Karger AG
Publication Date
Jul 08, 2020
Volume
99
Issue
7
Pages
598–605
Identifiers
DOI: 10.1159/000507265
PMID: 32640453
Source
Karger
Keywords
License
Green
External links

Abstract

Background: No clinical studies to date have compared unilateral lung or lobe volumes between the supine and standing positions. Objectives: To compare lung/lobe volumes on computed tomography (CT) between these two positions and evaluate the correlation between the total lung volume and total lung capacity (TLC) on pulmonary function tests (PFTs). Methods: Thirty-two asymptomatic volunteers underwent both conventional CT (supine position) and upright CT (standing position), during deep inspiration breath-hold, and PFTs on the same day. We measured lung/lobe volumes on CT in each position. Paired t tests were used for statistical analysis. Results: The volumes of the total lung (10.9% increase), right lung (10.3% increase), right upper lobe (8.6% increase), right lower lobe (14.6% increase), left lung (11.6% increase), left upper lobe (7.1% increase), and left lower lobe (16.0% increase) were significantly greater in the standing position than in the supine position (all p < 0.0001). The right middle lobe volume was similar between the two positions (p = 0.16). Intraclass correlation coefficients for agreement between total lung volumes on CT in the supine/standing positions and the TLC on PFT were 0.891/0.938, respectively. Conclusions: While the volumes of the bilateral upper and lower lobes and bilateral lungs were significantly greater in the standing than in the supine position, with lower lobes showing larger changes, the right middle lobe volume did not change significantly between positions. The total lung volume on upright CT in the standing position was more similar to TLC on PFT than that in the supine position.

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