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Differences of K562 leukemia cell clones in the pattern of monoclonal antibody binding and NK cell susceptibility.

Authors
  • Hering, S
  • Böttger, V
  • Jantscheff, P
  • Micheel, B
Type
Published Article
Journal
Biomedica biochimica acta
Publication Date
Jan 01, 1986
Volume
45
Issue
5
Pages
673–679
Identifiers
PMID: 3463302
Source
Medline
License
Unknown

Abstract

Fifty-three K562-clones were tested against three monoclonal anti-K562-antibodies (MoAbs). The individual NK-cell sensitivity of thirty-one K562-clones was evaluated simultaneously. It was found that considerable differences exist in the antibody binding between single clones and the parental cell line indicating antigenic heterogeneity in the K562 line. Some K562-clones showed increased NK-cell sensitivity in comparison with the uncloned cell line. However, no correlation was observed between both investigated parameters.

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