Affordable Access

deepdyve-link
Publisher Website

Differences in characteristics of pellets prepared by different pelletization methods.

Authors
  • Häring, Adam
  • Vetchý, David
  • Janovská, Lucie
  • Krejcová, Katerina
  • Rabisková, Miloslava
Type
Published Article
Journal
Drug development and industrial pharmacy
Publication Date
Mar 01, 2008
Volume
34
Issue
3
Pages
289–296
Identifiers
DOI: 10.1080/03639040701655960
PMID: 18363144
Source
Medline
License
Unknown

Abstract

Pellets are currently a very popular dosage form for oral application. They can be prepared by several pelletization techniques. Extrusion/spheronization, commonly used in the pharmaceutical industry, and modern agglomeration in a rotoprocessor were the methods chosen for pellet preparation in our study. Theophylline (in 10% to 65% concentration) was the model drug, lactose monohydrate was used as filler, microcrystalline cellulose Avicel PH 101 was thespheronization enhancer, and the wetting agent was purified water. Both techniques led to the formation of pellets of appropriate shape and mechanical properties. Pellets of a higher density, hardness, lower friability, and slightly slower dissolution profiles were obtained by extrusion/spheronization. This method of pelletization also led to production of particles with narrower size distribution and bigger yield of pellets with the requested size.

Report this publication

Statistics

Seen <100 times