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Differences between tumor necrosis factor-α receptors types 1 and 2 in the modulation of spinal glial cell activation and mechanical allodynia in a rat sciatic nerve injury model.

Authors
Type
Published Article
Journal
Spine
0362-2436
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Volume
38
Issue
1
Pages
11–16
Identifiers
DOI: 10.1097/BRS.0b013e3182610fa9
PMID: 22652595
Source
Medline
License
Unknown

Abstract

These results indicate that the microglial TNF-α p55 pathway played a more important role than the TNF-α p75 pathway in the pathogenesis of peripheral nerve injury pain. This suggests that future studies seeking to clarify neuropathic pain should target TNF-α and p55 receptors in microglia.

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