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Differences between tumor necrosis factor-α receptors types 1 and 2 in the modulation of spinal glial cell activation and mechanical allodynia in a rat sciatic nerve injury model.

Authors
  • Ishikawa, Tetsuhiro
  • Miyagi, Masayuki
  • Kamoda, Hiroto
  • Orita, Sumihisa
  • Eguchi, Yawara
  • Arai, Gen
  • Suzuki, Miyako
  • Sakuma, Yoshihiro
  • Oikawa, Yasuhiro
  • Inoue, Gen
  • Aoki, Yasuchika
  • Toyone, Tomoaki
  • Takahashi, Kazuhisa
  • Ohtori, Seiji
Type
Published Article
Journal
Spine
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Jan 01, 2013
Volume
38
Issue
1
Pages
11–16
Identifiers
DOI: 10.1097/BRS.0b013e3182610fa9
PMID: 22652595
Source
Medline
License
Unknown

Abstract

These results indicate that the microglial TNF-α p55 pathway played a more important role than the TNF-α p75 pathway in the pathogenesis of peripheral nerve injury pain. This suggests that future studies seeking to clarify neuropathic pain should target TNF-α and p55 receptors in microglia.

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