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Dietary total antioxidant capacity and severity of stenosis in patients with coronary artery disease.

Authors
  • Paknahad, Zamzam1, 2
  • Moosavian, Seyedeh Parisa1, 2
  • Jervekani, Zahra Teimouri3
  • Hasanzadeh, Akbar4
  • Hashemi, Mohammad3
  • 1 Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. , (Iran)
  • 2 Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. , (Iran)
  • 3 Cardiology Department, Isfahan University of Medical Sciences, Isfahan, Iran. , (Iran)
  • 4 Department of Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran. , (Iran)
Type
Published Article
Journal
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
Publication Date
Jun 01, 2021
Volume
91
Issue
3-4
Pages
235–241
Identifiers
DOI: 10.1024/0300-9831/a000622
PMID: 31984875
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Aim: Coronary artery disease (CAD) is a major cause of mortality worldwide. Many studies suggest that dietary antioxidant can offer significant protection against stroke, heart failure, and coronary heart disease. However, there is no study that assessed the association between dietary TAC and severity of stenosis in patients with CVD. The aim of this study was to investigate the association of dietary TAC and severity of stenosis in patients with coronary artery disease. Methods: Dietary and medical History of 160 patients with CAD were assessed. The extent of Stenosis was determined using the Gensini score. Dietary history was investigated by food frequency questionnaire (FFQ), and Dietary TAC was calculated by multiplying the average frequency of intake of each food by oxygen radical absorbance capacity (ORAC) content. Results: Across the Gensini score quartiles the dietary TAC, dietary hydrophilic TAC, dietary lipophilic TAC, and dietary phenolic TAC values were significantly increased in the highest quartile compared with the lowest quartile (dietary TAC (mmolTE/100 g):17.5 ± 1.82 vs. 11.2 ± 1.90; dietary hydrophilic TAC (mmolTE/100 g): 16.56 ± 1.29 vs. 10.74 ± 1.81; dietary lipophilic TAC (mmolTE/100 g): 0.55 ± 0.12 vs. 0.23 ± 0.09; dietary phenolic TAC (mmolTE/100 g):1.84 ± 0.31 vs. 0.98 ± 0.21; (P < 0.001 for all)). However, a non-significant association between the plasma TAC and Gensini quartiles was observed (P = 0.789). Multivariate regression analysis showed that dietary TAC (Beta = -0.53; P < 0.001) was statistically significant independent predictors that associated with the Gensini score values. Conclusions: There was a significant association between dietary TAC and severity of stenosis in patients with coronary artery disease.

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