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Dietary Polyphenol Intake is Associated with HDL-Cholesterol and A Better Profile of other Components of the Metabolic Syndrome: A PREDIMED-Plus Sub-Study

Authors
  • Castro-Barquero, Sara1, 2
  • Tresserra-Rimbau, Anna2, 3, 4, 5
  • Vitelli-Storelli, Facundo6
  • Doménech, Mónica1, 2
  • Salas-Salvadó, Jordi2, 3, 4, 5
  • Martín-Sánchez, Vicente6, 7
  • Rubín-García, María6
  • Buil-Cosiales, Pilar2, 8
  • Corella, Dolores2, 9
  • Fitó, Montserrat2, 10
  • Romaguera, Dora2, 11
  • Vioque, Jesús7,
  • Alonso-Gómez, Ángel María2, 12
  • Wärnberg, Julia2, 13
  • Martínez, José Alfredo2, 14,
  • Serra-Majem, Luís2, 15
  • Tinahones, Francisco José2, 16
  • Lapetra, José2, 17
  • Pintó, Xavier2,
  • Tur, Josep Antonio2, 11, 18
  • And 35 more
  • 1 (Á.H.)
  • 2 (R.M.L.-R.)
  • 3 Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Unitat de Nutrició, 43204 Reus, Spain
  • 4 University Hospital of Sant Joan de Reus, Nutrition Unit, 43201 Reus, Spain
  • 5 Institut d’Investigació Sanitària Pere Virgili (IISPV), 43201 Reus, Spain
  • 6 (M.R.-G.)
  • 7 (S.G.-P.)
  • 8 Servicio Navarro de Salud-Osasunbidea-Instituto de Investigación Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain
  • 9 Department of Preventive Medicine, University of Valencia, 46010 Valencia, Spain
  • 10 Cardiovascular Risk and Nutrition Research group, Institut Hospital del Mar de Investigaciones Médicas (IMIM), 08007 Barcelona, Spain
  • 11 Health Research Institute of the Balearic Islands (IdISBa), University Hospital Son Espases (Research Unit), 07120 Palma de Mallorca, Spain
  • 12 Bioaraba Health Research Institute; Osakidetza Basque Health Service, Araba University Hospital; University of the Basque Country UPV/EHU, 01009 Vitoria-Gasteiz, Spain
  • 13 Department of Nursing. University of Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), 29010 Málaga, Spain
  • 14 Department of Nutrition, Food Sciences, and Physiology, Center for Nutrition Research, University of Navarra, 31008 Pamplona, Spain
  • 15 & Centro Hospitalario Universitario Insular Materno Infantil (CHUIMI), Canarian Health Service, 35016 Las Palmas de Gran Canaria, Spain
  • 16 Virgen de la Victoria Hospital, Department of Endocrinology, Instituto de Investigación Biomédica de Málaga (IBIMA). University of Málaga, 29010 Málaga, Spain
  • 17 Department of Family Medicine, Research Unit, Distrito Sanitario Atención Primaria Sevilla, 41010 Sevilla, Spain
  • 18 Research Group on Community Nutrition & Oxidative Stress, University of Balearic Islands, 07122 Palma de Mallorca, Spain
  • 19 Department of Preventive Medicine and Public Health, University of Granada, 18016 Granada, Spain
  • 20 Division of Preventive Medicine, Faculty of Medicine, University of Jaén, 23071 Jaén, Spain
  • 21 Department of Endocrinology, Institut d’Investigacions Biomédiques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain
  • 22 Department of Endocrinology and Nutrition, Hospital Fundación Jimenez Díaz, Instituto de Investigaciones Biomédicas IISFJD. University Autonoma, 28040 Madrid, Spain
  • 23 Lipid Clinic, Department of Endocrinology and Nutrition, Institut d’Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clínic, 08036 Barcelona, Spain
  • 24 Unidad de Gestión Clínica de Endocrinología y Nutrición del Hospital Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), 29010 Málaga, Spain
  • 25 Department of Nutrition, Food Science and Gastronomy, XaRTA, INSA, School of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain
  • 26 Department of Internal Medicine, Hospital Clinic de Barcelona, 08036 Barcelona, Spain
Type
Published Article
Journal
Nutrients
Publisher
MDPI AG
Publication Date
Mar 04, 2020
Volume
12
Issue
3
Identifiers
DOI: 10.3390/nu12030689
PMID: 32143308
PMCID: PMC7146338
Source
PubMed Central
Keywords
License
Green

Abstract

Dietary polyphenol intake is associated with improvement of metabolic disturbances. The aims of the present study are to describe dietary polyphenol intake in a population with metabolic syndrome (MetS) and to examine the association between polyphenol intake and the components of MetS. This cross-sectional analysis involved 6633 men and women included in the PREDIMED (PREvención con DIeta MEDiterranea-Plus) study. The polyphenol content of foods was estimated from the Phenol-Explorer 3.6 database. The mean of total polyphenol intake was 846 ± 318 mg/day. Except for stilbenes, women had higher polyphenol intake than men. Total polyphenol intake was higher in older participants (>70 years of age) compared to their younger counterparts. Participants with body mass index (BMI) >35 kg/m2 reported lower total polyphenol, flavonoid, and stilbene intake than those with lower BMI. Total polyphenol intake was not associated with a better profile concerning MetS components, except for high-density lipoprotein cholesterol (HDL-c), although stilbenes, lignans, and other polyphenols showed an inverse association with blood pressure, fasting plasma glucose, and triglycerides. A direct association with HDL-c was found for all subclasses except lignans and phenolic acids. To conclude, in participants with MetS, higher intake of several polyphenol subclasses was associated with a better profile of MetS components, especially HDL-c.

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