Affordable Access

Access to the full text

Dietary Polyphenol Intake is Associated with HDL-Cholesterol and A Better Profile of other Components of the Metabolic Syndrome: A PREDIMED-Plus Sub-Study

  • Castro-Barquero, Sara1, 2
  • Tresserra-Rimbau, Anna2, 3, 4, 5
  • Vitelli-Storelli, Facundo6
  • Doménech, Mónica1, 2
  • Salas-Salvadó, Jordi2, 3, 4, 5
  • Martín-Sánchez, Vicente6, 7
  • Rubín-García, María6
  • Buil-Cosiales, Pilar2, 8
  • Corella, Dolores2, 9
  • Fitó, Montserrat2, 10
  • Romaguera, Dora2, 11
  • Vioque, Jesús7,
  • Alonso-Gómez, Ángel María2, 12
  • Wärnberg, Julia2, 13
  • Martínez, José Alfredo2, 14,
  • Serra-Majem, Luís2, 15
  • Tinahones, Francisco José2, 16
  • Lapetra, José2, 17
  • Pintó, Xavier2,
  • Tur, Josep Antonio2, 11, 18
  • And 35 more
  • 1 (Á.H.)
  • 2 (R.M.L.-R.)
  • 3 Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Unitat de Nutrició, 43204 Reus, Spain
  • 4 University Hospital of Sant Joan de Reus, Nutrition Unit, 43201 Reus, Spain
  • 5 Institut d’Investigació Sanitària Pere Virgili (IISPV), 43201 Reus, Spain
  • 6 (M.R.-G.)
  • 7 (S.G.-P.)
  • 8 Servicio Navarro de Salud-Osasunbidea-Instituto de Investigación Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain
  • 9 Department of Preventive Medicine, University of Valencia, 46010 Valencia, Spain
  • 10 Cardiovascular Risk and Nutrition Research group, Institut Hospital del Mar de Investigaciones Médicas (IMIM), 08007 Barcelona, Spain
  • 11 Health Research Institute of the Balearic Islands (IdISBa), University Hospital Son Espases (Research Unit), 07120 Palma de Mallorca, Spain
  • 12 Bioaraba Health Research Institute; Osakidetza Basque Health Service, Araba University Hospital; University of the Basque Country UPV/EHU, 01009 Vitoria-Gasteiz, Spain
  • 13 Department of Nursing. University of Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), 29010 Málaga, Spain
  • 14 Department of Nutrition, Food Sciences, and Physiology, Center for Nutrition Research, University of Navarra, 31008 Pamplona, Spain
  • 15 & Centro Hospitalario Universitario Insular Materno Infantil (CHUIMI), Canarian Health Service, 35016 Las Palmas de Gran Canaria, Spain
  • 16 Virgen de la Victoria Hospital, Department of Endocrinology, Instituto de Investigación Biomédica de Málaga (IBIMA). University of Málaga, 29010 Málaga, Spain
  • 17 Department of Family Medicine, Research Unit, Distrito Sanitario Atención Primaria Sevilla, 41010 Sevilla, Spain
  • 18 Research Group on Community Nutrition & Oxidative Stress, University of Balearic Islands, 07122 Palma de Mallorca, Spain
  • 19 Department of Preventive Medicine and Public Health, University of Granada, 18016 Granada, Spain
  • 20 Division of Preventive Medicine, Faculty of Medicine, University of Jaén, 23071 Jaén, Spain
  • 21 Department of Endocrinology, Institut d’Investigacions Biomédiques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain
  • 22 Department of Endocrinology and Nutrition, Hospital Fundación Jimenez Díaz, Instituto de Investigaciones Biomédicas IISFJD. University Autonoma, 28040 Madrid, Spain
  • 23 Lipid Clinic, Department of Endocrinology and Nutrition, Institut d’Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clínic, 08036 Barcelona, Spain
  • 24 Unidad de Gestión Clínica de Endocrinología y Nutrición del Hospital Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), 29010 Málaga, Spain
  • 25 Department of Nutrition, Food Science and Gastronomy, XaRTA, INSA, School of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain
  • 26 Department of Internal Medicine, Hospital Clinic de Barcelona, 08036 Barcelona, Spain
Published Article
Publication Date
Mar 04, 2020
DOI: 10.3390/nu12030689
PMID: 32143308
PMCID: PMC7146338
PubMed Central


Dietary polyphenol intake is associated with improvement of metabolic disturbances. The aims of the present study are to describe dietary polyphenol intake in a population with metabolic syndrome (MetS) and to examine the association between polyphenol intake and the components of MetS. This cross-sectional analysis involved 6633 men and women included in the PREDIMED (PREvención con DIeta MEDiterranea-Plus) study. The polyphenol content of foods was estimated from the Phenol-Explorer 3.6 database. The mean of total polyphenol intake was 846 ± 318 mg/day. Except for stilbenes, women had higher polyphenol intake than men. Total polyphenol intake was higher in older participants (>70 years of age) compared to their younger counterparts. Participants with body mass index (BMI) >35 kg/m2 reported lower total polyphenol, flavonoid, and stilbene intake than those with lower BMI. Total polyphenol intake was not associated with a better profile concerning MetS components, except for high-density lipoprotein cholesterol (HDL-c), although stilbenes, lignans, and other polyphenols showed an inverse association with blood pressure, fasting plasma glucose, and triglycerides. A direct association with HDL-c was found for all subclasses except lignans and phenolic acids. To conclude, in participants with MetS, higher intake of several polyphenol subclasses was associated with a better profile of MetS components, especially HDL-c.

Report this publication


Seen <100 times