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Dietary manipulation and progression of chronic renal failure.

Authors
  • Mitch, W E
Type
Published Article
Journal
Child nephrology and urology
Publication Date
Jan 01, 1991
Volume
11
Issue
3
Pages
134–139
Identifiers
PMID: 1777891
Source
Medline
License
Unknown

Abstract

Examination of the effects of dietary manipulation on progression of chronic renal failure (CRF) has been of interest for two reasons: dietary protein restriction is an effective method of ameliorating uremic symptoms and studies of changes in serum creatinine (and later, creatinine clearance or glomerular filtration rate, showed that the course of renal insufficiency is predictable. Results from studies of patients and animals with CRF suggested that a low-protein, phosphorus-restricted diet could slow the rate of loss of renal function. Animal studies have identified several mechanisms for progressive renal damage. These include glomerular hypertension causing capillary damage, glomerular damage from hypertrophic stimuli or hypermetabolism, calcium-phosphorus deposition and nephrotoxicity of the diet. The scientific basis for these different mechanisms will be discussed and each mechanism will be analyzed in terms of experimental studies in patients with CRF.

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