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Dietary Fiber and the Hippocampal Neurogenic Niche in a Model of Pelvic Radiotherapy.

Authors
  • Devarakonda, Sravani1
  • Malipatlolla, Dilip Kumar1
  • Patel, Piyush2
  • Grandér, Rita1
  • Kuhn, H Georg3
  • Steineck, Gunnar1
  • Sjöberg, Fei4
  • Rascón, Ana5
  • Nyman, Margareta5
  • Eriksson, Yohanna6
  • Danial, Jolie6
  • Ittner, Ella1
  • Naama Walid, Rukaya1
  • Prykhodko, Olena5
  • Masuram, Spandana1
  • Kalm, Marie6
  • Bull, Cecilia7
  • 1 Division of Clinical Cancer Epidemiology, Department of Oncology, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. , (Sweden)
  • 2 Division of Clinical Cancer Epidemiology, Department of Oncology, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Infectious Diseases, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. , (Sweden)
  • 3 Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. , (Sweden)
  • 4 Department of Infectious Diseases, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. , (Sweden)
  • 5 Department of Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden. , (Sweden)
  • 6 Department of Pharmacology, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. , (Sweden)
  • 7 Division of Clinical Cancer Epidemiology, Department of Oncology, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address: [email protected] , (Sweden)
Type
Published Article
Journal
Neuroscience
Publication Date
Nov 01, 2021
Volume
475
Pages
137–147
Identifiers
DOI: 10.1016/j.neuroscience.2021.08.030
PMID: 34487821
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

We sought to determine whether radiation to the colorectum had an impact on parameters of hippocampal neurogenesis and, if so, whether it could be modulated by a fiber-rich diet. Male C57BL/6J mice were fed a diet containing bioprocessed oat bran or a fiber-free diet, starting two weeks before colorectal irradiation with 4 fractions of 8 Gray or sham-irradiation. Diets were then continued for 1, 6 or 18 weeks, whereafter parameters of hippocampal neurogenesis were analyzed and correlated to serum cytokine levels. No statistically significant changes in neuronal markers or cell proliferation were found at one week post-irradiation. Six weeks post-irradiation there was a decreased cell proliferation in the subgranular zone that appeared slightly more pronounced in irradiated animals on a fiber-free diet and increased numbers of immature neurons per mm2 dentate gyrus in the irradiated mice, with a statistically significant increase in mice on a fiber-rich diet. Microglial abundancy was similar between all groups. 18 weeks post-irradiation, a fiber-free diet had reduced the number of immature neurons, whereas irradiation resulted in an increase. Despite this, the population of mature neurons was stable. Analysis of serum cytokines revealed a negative correlation between MIP1-α and the number of immature neurons one week after irradiation, regardless of diet. Our findings show that pelvic radiotherapy has the potential to cause a long-lasting impact on hippocampal neurogenesis, and dietary interventions may modulate this impact. More in-depth studies on the relationship between irradiation-induced intestinal injury and brain health are warranted. Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

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