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Dietary compounds as potent inhibitors of the signal transducers and activators of transcription (STAT) 3 regulatory network

Authors
Type
Published Article
Journal
Genes & Nutrition
Publisher
Springer-Verlag
Publication Date
Jan 25, 2012
Volume
7
Issue
2
Pages
125–125
Identifiers
DOI: 10.1007/s12263-012-0281-y
Source
LBMCC
Keywords
License
Green

Abstract

Signal transducers and activators of transcription (STAT) proteins were described as a family of latent cytosolic transcription factors whose activation is dependent on phosphorylation via growth factor- and cytokine-membrane receptors including interferon and interleukin, or by non-receptor intracellular tyrosine kinases, including Src. A vast majority of natural substances are capable of modulating mitogenic signals, cell survival, apoptosis, cell cycle regulation, angiogenesis as well as processes involved in metastasis development. The inhibition of STAT3 phosphorylation by natural and dietary compounds leads to decreased protein expression of STAT3 targets essentially involved in regulation of the cell cycle and apoptotic cell death. This review details the cell signaling pathways involving STAT transcription factors as well as the corresponding compounds from nature able to interfere with this regulatory system in human cancer.

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