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A diet rich in ( n−3) fatty acids increases peroxisomal β-oxidation activity and lowers plasma triacylglycerols without inhibiting glutathione-dependent detoxication activities in the rat liver

Authors
  • Yamazaki, Russell K.
  • Shen, Tingliang
  • Schade, G.Barbara
Type
Published Article
Journal
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
Publisher
Elsevier
Publication Date
Jan 01, 1987
Volume
920
Issue
1
Pages
62–67
Identifiers
DOI: 10.1016/0005-2760(87)90311-0
Source
Elsevier
Keywords
License
Unknown

Abstract

By using comparisons with a safflower oil diet (15% w/w) and a control, low-fat diet, the ability of a fish oil diet (15% MaxEPA TM) rich in the ( n−3) fatty acids, eicosapentaenoic acid and docosahexaenoic acid, to alter hepatic activities has been determined in adult, male rats. Compared with the safflower diet, treatment for 2 weeks with the fish oil diet caused significant increases in the ratio of liver weight/body weight and the specific activities in liver homogenates of peroxisomal enzymes fatty acyl-CoA oxidase (263%) and catalase (149%) and caused a significant lowering of plasma triacylglycerol levels. Fish oil diets rich in ( n−3) fatty acids should thus be placed in the category of hypotriglyceridemic agents which stimulate peroxisomal β-oxidation activity. In contrast to the effects seen with the other hypotriglyceridemic, peroxisomal proliferating agents such as clofibrate, hepatic glutathione peroxidase and glutathione S-transferase activities are unchanged or are increased rather than inhibited with the fish oil diet.

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