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Diet-induced changes in hypothalamic pro-opio-melanocortin mRNA in the rat hypothalamus.

Authors
  • Torri, Carla
  • Pedrazzi, Patrizia
  • Leo, Giuseppina
  • Müller, Eugenio E
  • Cocchi, Daniela
  • Agnati, Luigi F
  • Zoli, Michele
Type
Published Article
Journal
Peptides
Publisher
Elsevier
Publication Date
Jun 01, 2002
Volume
23
Issue
6
Pages
1063–1068
Identifiers
PMID: 12126732
Source
Medline
License
Unknown

Abstract

Hypothalamic mRNA and peptide levels of pro-opio-melanocortin (POMC) and other neuropeptides were studied in rats that either develop obesity (diet-induced obese, DIO), when fed a palatable and hypercaloric diet (cafeteria diet, caf) or do not develop obesity (diet resistant, DR), when fed the same diet. cafDIO rats showed a significant increase in POMC, but not in melanin concentrating hormone, mRNA levels as determined by semiquantitative in situ hybridization. cafDR and cafDIO rats showed no change in POMC-derived peptide levels, whereas neuropeptide Y immunoreactivity was significantly increased in cafDR rats. POMC mRNA levels were also studied in high-fat diet-fed rats but no significant change was observed. Altered hypothalamic transmission by POMC-derived peptides may contribute to the susceptibility of cafDIO rats to the weight promoting action of caf diet.

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