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Diastolic suction in heart failure: Impact of left ventricular geometry, untwist, and flow mechanics

Authors
  • Nogami, Yoshie
  • Ishizu, Tomoko
  • Atsumi, Akiko
  • Yamamoto, Masayoshi
  • Nakamura, Akihiro
  • Machino-Ohtsuka, Tomoko
  • Kawamura, Ryo
  • Seo, Yoshihiro
  • Aonuma, Kazutaka1, 2, 3, 4, 5, 3
  • 1 Faculty of Medicine
  • 2 Division of Clinical Medicine
  • 3 University of Tsukuba
  • 4 Division of Child Health
  • 5 Graduate School of Comprehensive Human Sciences
Type
Published Article
Journal
Life Sciences
Publisher
Elsevier
Publication Date
Jan 01, 2014
Accepted Date
Mar 09, 2014
Identifiers
DOI: 10.1016/j.lfs.2014.03.016
Source
Elsevier
Keywords
License
Unknown

Abstract

AimsVector flow mapping (VFM) can be used to assess intraventricular hemodynamics quantitatively. This study assessed the magnitude of the suction flow kinetic energy with VFM and investigated the relation between left ventricular (LV) function and geometry in patients with an estimated elevated LV filling pressure. Materials and methodsWe studied 24 subjects with an elevated LV filling pressure (EFP group) and 36 normal subjects (normal group). Suction was defined as flow directed toward the apex during the period from soon after systolic ejection to before mitral inflow. The flow kinetic energy index was quantified as the sum of the product of the blood mass and velocity vector and its magnitude to the peak value was measured. Key findingsSuction flow was observed in 12 (50%) EFP-group patients and 36 (100%) normal-group subjects. The magnitude of the suction kinetic energy index was significantly smaller in EFP versus normal group (2.7±3.8 vs. 5.7±4.4g/s/cm2, P<0.01). The EFP-group patients with suction had a smaller LV end-systolic volume (ESV) (P<0.01), greater ellipsoidal geometry (P<0.05) and untwisting rate (P<0.01) than the EFP-group patients without suction. A regression analysis indicated a significant linear relation between the suction kinetic energy index and LVEF (r=0.43, P=0.04), ESV (r=−0.40, P=0.05), eccentricity index (r=0.44, P=0.04), and untwisting rate (r=0.51, P=0.04). SignificanceThe magnitude of the suction flow kinetic energy index derived from VFM may allow the quantitative assessment of the suction flow, which correlates with LV systolic function, geometry, and untwisting mechanics.

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