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Diarylheptanoids with NO production inhibitory activity from Amomum kravanh.

Authors
  • Zhang, Jun-Sheng1
  • Cao, Xin-Xin1
  • Yu, Jin-Hai1
  • Yu, Zhi-Pu1
  • Zhang, Hua2
  • 1 School of Biological Science and Technology, University of Jinan, Jinan, China. , (China)
  • 2 School of Biological Science and Technology, University of Jinan, Jinan, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Bioorganic & medicinal chemistry letters
Publication Date
Apr 15, 2020
Volume
30
Issue
8
Pages
127026–127026
Identifiers
DOI: 10.1016/j.bmcl.2020.127026
PMID: 32070636
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Seven new diarylheptanoids, kravanhols C-I (1-7), along with two known analogues (8 and 9), were isolated from the fruits of Amomum kravanh. The structures of compounds 1-7 were elucidated by analysis of spectroscopic data, and the absolute configurations of selective ones were determined by time-dependent density functional theory (TD-DFT) based electronic circular dichroism (ECD) calculations. All compounds were evaluated for their inhibitory effects on the nitric oxide (NO) production induced by lipopolysaccharide (LPS) in murine RAW264.7 macrophage cells. Compounds 2, 5, 6 and 9 exhibited moderate inhibitory activity with IC50 values in the range of 17.4-26.5 μM, being more potent than the positive control dexamethasone (IC50 = 32.5 μM). Copyright © 2020 Elsevier Ltd. All rights reserved.

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