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Diaphragm pacing in amyotrophic lateral sclerosis: a literature review.

Authors
  • Scherer, Katalin
  • Bedlack, Richard S
Type
Published Article
Journal
Muscle & Nerve
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jul 01, 2012
Volume
46
Issue
1
Pages
1–8
Identifiers
DOI: 10.1002/mus.23419
PMID: 22692995
Source
Medline
License
Unknown

Abstract

Amyotrophic lateral sclerosis (ALS) remains a rapidly progressive fatal degenerative disease of motor neurons for which there are few interventions to slow disease progression or improve quality of life. A diaphragm pacing system was approved by the U.S. Food and Drug Administration in September 2011 for ALS under a Humanitarian Device Exemption. News of this approval has been met with a combination of excitement and uncertainty by members of the ALS community. We review the currently available data on the diaphragm pacing system and its use in ALS. Diaphragm pacing appears to be reasonably safe in carefully selected patients, but flaws in the reporting on it thus far preclude conclusions regarding efficacy. Further study is needed.

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