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Diammonium hydrogen phosphate as a versatile and efficient catalyst for the one-pot synthesis of pyrano[2,3-d]pyrimidinone derivatives in aqueous media.

Authors
Type
Published Article
Journal
Molecular diversity
Publication Date
Volume
12
Issue
2
Pages
85–91
Identifiers
DOI: 10.1007/s11030-008-9079-7
PMID: 18512127
Source
Medline
License
Unknown

Abstract

Diammonium hydrogen phosphate, (NH4)2HPO4, was used as a catalyst for one-pot, three-component condensation reactions consisting of aromatic aldehydes, malononitrile and barbituric/thiobarbituric acid in aqueous ethanol at room temperature. This method has the advantages of a simple operation, mild reaction conditions, high yields, by using a less toxic and low cost chemical as a catalyst.

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