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[Diagnostics and therapy for neuroendocrine neoplasia of an unknown primary - a plea for open exploration].

Authors
  • Begum, N
  • Hubold, C
  • Buchmann, I
  • Thorns, C
  • Bouchard, R
  • Lubienski, A
  • Schlöricke, E
  • Zimmermann, M
  • Lehnert, H
  • Bruch, H-P
  • Bürk, C G
Type
Published Article
Journal
Zentralblatt für Chirurgie
Publication Date
Jun 01, 2014
Volume
139
Issue
3
Pages
284–291
Identifiers
DOI: 10.1055/s-0032-1327962
PMID: 23508839
Source
Medline
License
Unknown

Abstract

Primary tumours of the midgut and pancreas are often found in the subset of well differentiated neuroendocrine CUP syndrome after open surgical exploration. A high rate of complete tumour resection and cure can be achieved in these cases. After common diagnostic tools (CT, MRI and somatostatin receptor scintigraphy), immunhistochemistry can give important hints (CDX-2 for midgut, TTF-1 for lung and thyroid) for a primary lesion. Also in single site metastasis without primary tumour detection a good clinical outcome is seen after complete resection.

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