Affordable Access

deepdyve-link
Publisher Website

Diagnostic and Prognostic Value of Immune/Inflammation Biomarkers for Venous Thromboembolism: Is It Reliable for Clinical Practice?

Authors
  • Xue, Junshuai1
  • Ma, Delin2
  • Jiang, Jianjun1
  • Liu, Yang1
  • 1 Department of General Surgery, Vascular Surgery, Shandong University Qilu Hospital, Jinan City, Shandong Province
  • 2 Department of General Surgery, Shandong University Qilu Hospital, Jinan City, Shandong Province
Type
Published Article
Journal
Journal of Inflammation Research
Publisher
Dove
Publication Date
Oct 02, 2021
Volume
14
Pages
5059–5077
Identifiers
DOI: 10.2147/JIR.S327014
PMCID: PMC8494998
Source
PubMed Central
Keywords
Disciplines
  • Review
License
Unknown

Abstract

Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), has been an important cause of sudden in-hospital death. Studies have shown that the immune/inflammatory response plays an important role in the pathogenesis of vascular disease, with representative markers in the blood including the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), systemic immune/inflammatory index (SII), etc. However, there is a variety of immune/inflammatory indicators. Moreover, most previous studies have been single-center investigations involving one or two indicators, with varying nature of cases, number of cases and study objectives, thereby making it difficult to reach consensus conclusions with good clinical guidelines. This article reviews the clinical value of immunoinflammatory indicators for VTE based on previous studies, including the diagnostic and prognostic capabilities. In conclusion, NLR provides promising predictive capability for the onset and prognosis of VTE and deserves extensive application in clinical practice. PLR also has certain diagnostic and prognostic value, but further studies are warranted to identify its reliability and stability. Monocytes, eosinophils and platelet-related indicators show some clinical association with VTE, although the predictive capabilities are mediocre. SII is of promising potential value for VTE and deserves further investigations. This review will provide new clues and valuable clinical guidance for the diagnosis and therapy of VTE.

Report this publication

Statistics

Seen <100 times