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Diagnostic imaging in the clinical management of patients at high risk for breast cancer.

Authors
  • Pastore, Giovanna
  • Canadè, Adolfo
  • Costantini, Melania
  • Terribile, Daniela
  • Nardone, Luigia
  • Belli, Paolo
Type
Published Article
Journal
Rays
Publication Date
Jan 01, 2002
Volume
27
Issue
4
Pages
295–298
Identifiers
PMID: 12703481
Source
Medline
License
Unknown

Abstract

Although being predominantly anecdotal, breast carcinoma shows a considerable component of multifactorial genetic transmission, referable to dominant autosomal inheritance. Among the genes responsible for hereditary breast cancer two main genes (BRCA1 and BRCA2) have already been identified. At present, genetic tests to identify known inherited mutations associated with breast tumor predisposition, are available. Asymptomatic subjects with genetic BRCA1/2 mutations represent a group at high risk; therefore it is now indispensable to work out adequate strategies of prevention and/or of early diagnosis. Besides education (information) and genetic counselling, there are three perspectives of intervention for these subjects: bilateral prophylactic surgery, pharmacologic prophylaxis and periodical diagnostic monitoring; unfortunately all of them are still burdened by limitations.

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