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Diagnostic contribution of focal cortical dysplasia MRI imaging findings and ADC values

Authors
  • Aslan, Aydın
  • Deniz, Muhammed Akif
  • Taş Deniz, Zelal
  • Turmak, Mehmet
  • Ekici, Faysal
Type
Published Article
Journal
Egyptian Journal of Radiology and Nuclear Medicine
Publisher
Springer Berlin Heidelberg
Publication Date
Sep 06, 2019
Volume
50
Issue
1
Identifiers
DOI: 10.1186/s43055-019-0022-y
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundFocal cortical dysplasia (FCD) is a condition that often interferes with the cranial mass. Knowledge of focal cortical dysplasia magnetic resonance imaging (MRI) characteristics is of utmost importance for diagnosis. This study aimed to determine the diagnostic contribution of cranial MRI and the apparent diffusion coefficient (ADC) in FCD.ResultsCranial MRI revealed subcortical hyperintensity (SCH) in 52 patients (82.5%), blurring of the gray-white matter (GWM) interface (blurring) in 52 patients (82.5%), cortical thickening (CT) in 48 patients (76%), cortical signal increase (CSI) in 41 patients (65%), and transmantle sign (TMS) in 29 patients (46%). All of the FCDs had a diffusion increase in diffusion-weighted images (DWIs). The mean ADC value at the lesion level was 1.087 × 10−3 mm2/s (0.82/1.316 × 10−3 mm2/s), which was significantly higher than the mean ADC value measured from the contralateral symmetric region (0.758 × 10−3 mm2/s, 0.678/0.872 × 10−3 mm2/s, p = 0.001).ConclusionResults of this study revealed that the most common MRI findings in FCD patients are SCH, blurring, and CT. These findings aid in an easier diagnosis in patients with suspected FCD. All of the lesions studied here in had a diffusion increase in DWI. The quantitative mean ADC values detected in the differential diagnosis of other lesions with a diffusion increase can be used as a reference. Therefore, in addition to the ADC values and electroencephalography (EEG) findings, the conventional MRI findings of FCD, which is resistant to medical treatment, can help to facilitate the diagnosis of FCD, which can be treated with surgery.

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