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Diagnosis of human immunodeficiency virus (HIV) infection: multicenter evaluation of a newly developed anti-HIV 1 and 2 enzyme immunoassay.

Authors
  • Hess, G
  • Avillez, F
  • Lourenco, M H
  • D'Agostino, F
  • Cambie, G
  • Piot, P
  • Vercauteren, G
  • Michl, U
  • Melchior, W
  • Bayer, H
Type
Published Article
Journal
Journal of clinical microbiology
Publication Date
Feb 01, 1994
Volume
32
Issue
2
Pages
403–406
Identifiers
PMID: 8150950
Source
Medline
License
Unknown

Abstract

A new anti-human immunodeficiency virus type 1 and 2 (anti-HIV 1 and 2) test is described. It uses recombinant p24 and peptides covering gp32, gp41, and gp120 to identify HIV-1 and HIV-2 infections. This test has been shown to be specific (99.5%) and sensitive (99.8%). In this respect, the assay was equal or superior to anti-HIV 1 and 2 tests run as references. The test was able to discriminate sera from patients with HIV infections from those from uninfected individuals with excellence; it also exerted high intra- and interassay precisions. The "modular" concept of the test allows the use of single components (gp32 or gp41) to separate between HIV-2 and HIV-1 infections, respectively.

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