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Diagnosis of fetal rubella infection by nucleic acid hybridization.

Authors
Type
Published Article
Journal
Journal of medical virology
Publication Date
Volume
24
Issue
2
Pages
175–182
Identifiers
PMID: 3351485
Source
Medline

Abstract

The efficacy of nucleic acid hybridization for the diagnosis of rubella infection in experimental and clinical materials was compared with immunoblot and virus isolation techniques. Our results showed that nucleic acid hybridization is specific and rapid but gives false-negative results when compared with conventional virus isolation in some experimental although not in clinical materials so far examined. For this reason, a failure to demonstrate rubella virus in fetal specimens by this method alone cannot yet be taken as a sole criterion for ruling out fetal rubella infection.

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