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Diagnosis of Concurrent Pulmonary Tuberculosis and Tuberculous Otitis Media Confirmed by Xpert MTB/RIF in the United States.

Authors
  • Tompkins, Kathleen M1
  • Reimers, Melissa A2
  • White, Becky L3
  • Herce, Michael E4
  • 1 The University of North Carolina at Chapel Hill School of Medicine.
  • 2 University of North Carolina at Chapel Hill, Department of Internal Medicine.
  • 3 University of North Carolina at Chapel Hill School of Medicine, Department of Medicine, Division of infectious diseases.
  • 4 University of North Carolina at Chapel Hill School of Medicine, Department of Medicine, Division of infectious diseases; Centre for Infectious Disease Research in Zambia (CIDRZ). , (Zambia)
Type
Published Article
Journal
Infectious diseases in clinical practice (Baltimore, Md.)
Publication Date
May 01, 2016
Volume
24
Issue
3
Pages
180–182
Identifiers
PMID: 27346926
Source
Medline
Keywords
License
Unknown

Abstract

Tuberculosis (TB) remains an important cause of infectious morbidity in the United States (US), necessitating timely and accurate diagnosis. We report a case of concurrent pulmonary and extrapulmonary TB presenting as tuberculous otitis media in a hospitalized US patient admitted with cough, night sweats, and unilateral purulent otorrhea. Diagnosis was made by smear microscopy and rapidly confirmed by Xpert MTB/RIF-a novel, automated nucleic acid amplification test for the rapid detection of drug-susceptible and drug-resistant TB. This case adds to the growing body of evidence validating Xpert MTB/RIF as an effective tool for the rapid diagnosis of extrapulmonary TB, even in low TB-prevalence settings such as the US, when testing is performed on non-respiratory specimens.

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