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Diagnosing human blood clotting deficiency.

Authors
  • Ong, Chong Cheen1
  • Gopinath, Subash C B2
  • Rebecca, Leong Wei Xian1
  • Perumal, Veeradasan3
  • Lakshmipriya, Thangavel4
  • Saheed, Mohamed Shuaib Mohamed1
  • 1 Department of Fundamental & Applied Science, Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak Darul Ridzuan, Malaysia.; Centre of Innovative Nanostructure & Nanodevices (COINN), Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak Darul Ridzuan, Malaysia. , (Malaysia)
  • 2 School of Bioprocess Engineering, Universiti Malaysia Perlis, 02600 Arau, Perlis, Malaysia; Institute of Nano Electronic Engineering, University Malaysia Perlis, 01000 Kangar, Perlis, Malaysia. Electronic address: [email protected] , (Malaysia)
  • 3 Centre of Innovative Nanostructure & Nanodevices (COINN), Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak Darul Ridzuan, Malaysia; Department of Mechanical Engineering, Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak Darul Ridzuan, Malaysia. , (Malaysia)
  • 4 Centre of Innovative Nanostructure & Nanodevices (COINN), Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak Darul Ridzuan, Malaysia. , (Malaysia)
Type
Published Article
Journal
International journal of biological macromolecules
Publication Date
May 15, 2018
Volume
116
Pages
765–773
Identifiers
DOI: 10.1016/j.ijbiomac.2018.05.084
PMID: 29775720
Source
Medline
Keywords
License
Unknown

Abstract

There are different clotting factors present in blood, carries the clotting cascade and excessive bleeding may cause a deficiency in the clotting Diagnosis of this deficiency in clotting drastically reduces the potential fatality. For enabling a sensor to detect the clotting factors, suitable probes such as antibody and aptamer have been used to capture these targets on the sensing surface. Two major clotting factors were widely studied for the diagnosis of clotting deficiency, which includes factor IX and thrombin. In addition, factor IX is considered as the substitute for heparin and the prothrombotic associated with the increased thrombin generation are taking into account their prevalence. The biosensors, surface plasmon resonance, evanescent-field-coupled waveguide-mode sensor, metal-enhanced PicoGreen fluorescence and electrochemical aptasensor were well-documented and improvements have been made for high-performance sensing. We overviewed detecting factor IX and thrombin using these biosensors, for the potential application in medical diagnosis.

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