Affordable Access

deepdyve-link
Publisher Website

Diacylglycerols as biomarkers of sustained immune activation in Proteinopathies associated with dementia.

Authors
  • Wood, Paul L1
  • Cebak, John E2
  • Woltjer, Randall L3
  • 1 Metabolomics Unit, College of Veterinary Medicine, Lincoln Memorial University, 6965 Cumberland Gap Pkwy., Harrogate, TN 37752, United States. Electronic address: [email protected] , (United States)
  • 2 Department of Medicine, DeBusk College of Osteopathic Medicine, Lincoln Memorial University, 6965 Cumberland Gap Pkwy., Harrogate, TN 37752, United States. , (United States)
  • 3 Dept. of Neurology, Oregon Health Science University, Portland VA Medical Center, Portland, OR 9723, United States. , (United States)
Type
Published Article
Journal
Clinica chimica acta; international journal of clinical chemistry
Publication Date
Nov 13, 2017
Identifiers
DOI: 10.1016/j.cca.2017.11.009
PMID: 29146478
Source
Medline
Keywords
License
Unknown

Abstract

Cognitive decline is a devastating clinical condition, heavily correlated with age progression. In the cases of Alzheimer's disease, Parkinson's disease, and Lewy body disease, the common neuropathologies are proteinopathies and neuroinflammation. Herein, we review current lipidomics findings and conclude that brain and circulating diacylglycerols represent biomarkers of this ongoing sustained immune response, presumably involving microglia. We further hypothesize that a logical next step will be to evaluate biomarkers of immune activation in a cohort of patients with Mild Cognitive Impairment (MCI) and subsequently attempt to provide therapeutic intervention with anti-inflammatory therapy in MCI patients with immune activation. Although this is an urgent and theoretically safe therapeutic trial, it will likely necessitate government support.

Report this publication

Statistics

Seen <100 times