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Diabetes mellitus: in search of an improved classification and treatment algorithm

Authors
  • Cernea, Simona
  • Cahn, Avivit
Type
Published Article
Journal
Revista Romana de Medicina de Laborator
Publisher
De Gruyter Open Sp. z o.o.
Publication Date
Mar 01, 2016
Volume
24
Issue
1
Pages
9–20
Identifiers
DOI: 10.1515/rrlm-2016-0001
Source
De Gruyter
Keywords
License
Green

Abstract

Our current clinical doctrine and practice is based upon a classification of diabetes which relies mainly on some clinical manifestations/criteria, rather than markers of the pathophysiological mechanisms of the disease. An improved classification based on such biological markers (i.e. of insulin resistance, beta cell dysfunction, autoimmunity) may assist in clinical decision and may offer the opportunity of an optimized therapeutic strategy. We address here some important questions that have not yet been clarified, e.g. which markers/indicators best define the main pathogenic mechanisms of the disease in a patient with diabetes and what threshold values are relevant for this purpose.

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