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Diabetes enhances the proliferation of adult pancreatic multipotent progenitor cells and biases their differentiation to more β-cell production.

Authors
  • Razavi, Rozita
  • Najafabadi, Hamed S
  • Abdullah, Sarah
  • Smukler, Simon
  • Arntfield, Margot
  • van der Kooy, Derek
Type
Published Article
Journal
Diabetes
Publisher
American Diabetes Association
Publication Date
Apr 01, 2015
Volume
64
Issue
4
Pages
1311–1323
Identifiers
DOI: 10.2337/db14-0070
PMID: 25392245
Source
Medline
License
Unknown

Abstract

Endogenous pancreatic multipotent progenitors (PMPs) are ideal candidates for regenerative approaches to compensate for β-cell loss since their β-cell-producing capacities as well as strategic location would eliminate unnecessary invasive manipulations. However, little is known about the status and potentials of PMPs under diabetic conditions. Here we show that β-cell metabolic stress and hyperglycemia enhance the proliferation capacities of adult PMP cells and bias their production of progeny toward β-cells in mouse and human. These effects are dynamic and correlate with functional β-cell regeneration when conditions allow.

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