Interaction between Alcohol Consumption and CYP 2C19 Gene Polymorphism in Relation to Oesophageal Squamous Cell Carcinoma

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Interaction between Alcohol Consumption and CYP 2C19 Gene Polymorphism in Relation to Oesophageal Squamous Cell Carcinoma

Authors
Publisher
Public Library of Science
Volume
7
Issue
9
Identifiers
DOI: 10.1371/journal.pone.0043412
Keywords
  • Oncology
  • Biology
  • Medicine
  • Genetics
  • Public Health
  • Alcohol
  • Cancer Genetics
  • Research Article
  • Esophageal Cancer
  • Clinical Genetics
  • Gastrointestinal Tumors
  • Esophagus
  • Molecular Cell Biology
  • Gastroenterology And Hepatology
  • Basic Cancer Research
  • Cancers And Neoplasms
  • Cancer Risk Factors
  • Genetic Causes Of Cancer

Abstract

Objectives The purpose of this study is to explore the relationship between the interactions of CYP2C19 gene polymorphisms and several environmental factors and oesophageal squamous cell carcinoma (OSCC). Methods In a case-control study of OSCC patients (n = 350) and healthy controls (n = 350), we investigated the roles of polymorphism in the CYP2C19 gene by the use of polymerase chain reaction - restriction fragment length polymorphism (PCR – RFLP) analysis. Results The CYP2C19*3 AG+AA genotype was significantly more prevalent in OSCC patients (10.0% versus 3.43%; P<0.01). Multiple logistic regression analysis showed drinking (OR: 5.603, 95% CI: 3.431–11.112; P = 0.005) and smoking (OR: 4.341, 95% CI: 3.425–10.241; P = 0.001) was the independent risk factor of OSCC respectively, and there were significant interaction between CYP2C19*3 and drinking (OR: 8.747, 95% CI: 6.321–18.122; P = 0.009). Conclusions The CYP2C19*3 polymorphism and OSCC were synergistically and significantly associated in Chinese Han patients.

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