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The binding of basic fibroblast growth factor to Alzheimer's neurofibrillary tangles and senile plaques

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
122
Issue
1
Identifiers
DOI: 10.1016/0304-3940(91)90186-w
Keywords
  • Alzheimer'S Disease
  • Basic Fibroblast Growth Factor
  • Acidic Fibroblast Growth Factor
  • Heparan Sulfate
  • Proteoglycan
  • β-Protein
  • A4
  • Basic Fibroblast Growth Factor-Binding Site
Disciplines
  • Chemistry
  • Medicine

Abstract

Abstract Brain sections from Alzheimer's disease (AD) patients and controls were treated with basic fibroblast growth factor (bFGF) and then immunostained with anti-bFGF. Additional sections were treated with biotinylated bFGF without using the anti-bFGF. Labelling was visualized by the ABC method. Both protocols above intensely labelled neurofibrillary tangles, senile plaques and amyloidotic vessels in AD brains. Omission of the bFGF treatment abolished the staining of the AD lesions. The pretreatment of sections with heparitinase also reduced their staining. These results indicate that AD lesions contain bFGF-binding sites and that the chemical substrate for bFGF binding to AD lesions was heparan sulfate.

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