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Syntheses and biological evaluation of novel pseudomycin side-chain analogues. Part 2

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
10
Issue
18
Identifiers
DOI: 10.1016/s0960-894x(00)00424-8

Abstract

Abstract A series of aliphatic side-chain analogues of pseudomycin was synthesized and evaluated during the course of our side-chain SAR effort. We found that several of the pseudomycin side-chain analogues (e.g., 10) exhibited good in vitro activity against all three major fungi responsible for systemic fungal infections.

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