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Effect of nerve section on β-endorphin and α-melanotropin immunoreactivity in motor nerves of normal and dystrophic mice

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
92
Issue
1
Identifiers
DOI: 10.1016/0304-3940(88)90732-x
Keywords
  • β-Endorphin
  • α-Melanotropin
  • Muscular Dystrophy
  • Motor Nerve
  • Muscle Endplate
Disciplines
  • Biology
  • Medicine

Abstract

Abstract β-Endorphin and α-melanotropin immunoreactivity was demonstrated in some motor nerves in histological sections of soleus and extensor digitorum longus muscles of the mouse. In two strains (C57BL/6J and 129/ReJ) which can inherit muscular dystrophy, the proportion of immunoreactive nerves was greater in the dystrophic individuals than in their healthy littermates. At 24 h after section of the sciatic nerve in the normal mice the proportion of immunoreactive nerve profiles had increased significantly in the denervated muscles even though most of the nerve axons had degenerated. Similar increases were also seen in nerves in the unoperated contralateral muscles.

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