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Melatonin activates Th1 lymphocytes by increasing IL-12 production

Authors
Journal
Life Sciences
0024-3205
Publisher
Elsevier
Publication Date
Volume
65
Issue
20
Identifiers
DOI: 10.1016/s0024-3205(99)00479-8
Keywords
  • Melatonin
  • Th1 Lymphocytes
  • Ifn-γ
  • Il-6
  • Il-12

Abstract

Abstract Melatonin could act on immune system by regulating cytokine production of immunocompetent cells. The hormone enhances IL-2, IFN-γ and IL-6 production by cultured human mononuclear cells. As enhancement of IL-6 production is related to monocyte activation by melatonin, the hormone acts on human lymphoid cells causing a Th1-type response. This paper shows that melatonin seems to promote a Th1-response by increasing IL-12 production. The hormone enhances IL-12 production by cultured monocytes under suboptimal stimulation in a dose-dependent way. The effect of the hormone increases when PBMCs are incubated with melatonin before monocyte isolation. Enhanced IL-12 production by melatonin can also be shown in cultured human mononuclear cells.

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