Affordable Access

Publisher Website

The role of polymorphisms of genes encoding collagen IX and XI in lumbar disc disease

Authors
Journal
Neurologia i Neurochirurgia Polska
0028-3843
Publisher
Elsevier
Volume
48
Issue
1
Identifiers
DOI: 10.1016/j.pjnns.2013.04.001
Keywords
  • Intervertebral Disc Disease
  • Gene Polymorphism
  • Col9A2
  • Col9A3
  • Col11A1
Disciplines
  • Medicine

Abstract

Abstract The intervertebral disc disease (IDD) is one of the most common musculoskeletal disorders. A number of environment and anthropometric risk factors may contribute to it. The recent reports have suggested the importance of genetic factors, especially these which encode collagen types IX and XI. The allelic variants in the collagen IX genes – COL9A2 (Trp2) and COL9A3 (Trp3) have been identified as genetic risk factors for IDD, because they interfere the cross-linking between collagen types II, IX and XI and result in decreased stability of intervertebral discs. Type XI collagen is a minor component of cartilage collagen fibrils, but it is present in the annulus fibrosus and nucleus pulposus of intervertebral discs. Some studies have shown the association between gene COL11A1 polymorphism c.4603C>T and IDD. The frequency of 4603T allele was significantly higher in the patients with IDD than in the healthy controls.

There are no comments yet on this publication. Be the first to share your thoughts.