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Sunthetic Studies of Microsclerodermins. A Stereoselective Synthesis of a Core Building Block for (2S,3R, 4S,5S,6S, 11E)-3-Amino-6-methyl-12-(4-methoxyphenyl)-2,4,5-trihydroxydodec-11-enoic Acid (AMMTD)

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
38
Issue
17
Identifiers
DOI: 10.1016/s0040-4039(97)00522-4

Abstract

Abstract A core building block 3 for (2 S,3 R,4 S,5 S,6 S,11 E)-3-amino-6-methyl-12-(4-methoxyphenyl)-2,4,5-trihydroxydodec- 11-enoic acid ( 2, AMMTD) has been efficiently synthesized using the Sharpless asymmetric dihydroxylation and the Dondoni's furan addition to a nitrone derivative as key steps. The 2-furyl group has been used as the carboxyl synthon. © 1997 Elsevier Science Ltd.

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