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Effect of Drinking on Adiponectin in Healthy Men and Women : A randomized intervention study of water, ethanol, red wine, and beer with or without alcohol

Authors
Journal
Diabetes Care
0149-5992
Publisher
American Diabetes Association
Publication Date
Volume
32
Issue
6
Identifiers
DOI: 10.2337/dc08-1723
Keywords
  • Original Research
  • Cardiovascular And Metabolic Risk
Disciplines
  • Biology
  • Medicine

Abstract

OBJECTIVE Moderate alcohol consumption is associated with reduced incidence of type 2 diabetes and cardiovascular mortality and increases adiponectin concentrations, but effects might differ according to sex and beverage consumed. RESEARCH DESIGN AND METHODS A total of 72 healthy individuals (22–56 years) were enrolled in this randomized controlled crossover trial. After washout, two interventions for 3 weeks followed: ethanol (concentration 12.5%), beer (5.6%), or red wine (12.5%) equivalent to 30 g ethanol/day for men and 20 g/day for women or the same de-alcoholized beverages or water. Adiponectin was measured by sandwich enzyme-linked immunosorbent assay. RESULTS Among women, adiponectin significantly increased after consuming red wine (29.8%, P < 0.05) and increased among men after ethanol solution (17.4%, P < 0.05) and consuming beer (16.1%, P < 0.05). De-alcoholized beverages had no substantial effect on adiponectin concentrations. CONCLUSIONS Moderate amounts of ethanol-containing beverages increased adiponectin concentrations, but sex-specific effects might depend on type of beverage consumed.

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