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The dorsal noradrenergic bundle, extinction and non-reward

Authors
Journal
Physiology & Behavior
0031-9384
Publisher
Elsevier
Publication Date
Volume
21
Issue
6
Identifiers
DOI: 10.1016/0031-9384(78)90184-1
Keywords
  • Noradrenaline
  • Locus Coeruleus
  • Dorsal Bundle
  • 6-Hydroxydopamine
  • Extinction
  • Non-Reward
  • Dbee

Abstract

Abstract Lesion to the dorsal noradrenergic bundle using 6-hydroxydopamine produces resistance to extinction which might be due to an inability to code for non-reward. 6-Hydroxydopamine lesioned rats were tested on a double fixed interval (FI) schedule to assess the response invigourating effects of non-reward and the acquisition of a new lever pressing response to terminate a stimulus associated with non-reward was used to assess the aversiveness of non-reward. Neither of these effects were altered after the 6-OHDA lesion, but resistance to extinction was seen on the FI schedule. It is concluded that an inability to code for non-reward is not the basis of the dorsal bundle extinction effect.

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