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Dexamethasone and sphingolipids inhibit concanavalin A stimulated glucose uptake in 3T3-L1 fibroblasts.

Authors
  • Nelson, D H
  • Murray, D K
Type
Published Article
Journal
Endocrine research
Publication Date
Jan 01, 1988
Volume
14
Issue
4
Pages
305–318
Identifiers
PMID: 3074919
Source
Medline
License
Unknown

Abstract

Studies were carried out in 3T3-L1 fibroblasts to determine the effect of sphingolipids and corticosteroids on concanavalin A stimulated glucose uptake. Sphinganine (40 microM) and sphingosine (40 AND 100 microM) significantly inhibited concanavalin A stimulated glucose uptake (P less than 0.025 & less than 0.005). Prior incubation with 10(-7) M dexamethasone also significantly inhibited concanavalin A stimulated glucose uptake (P less than 0.005). The known effects of corticosteroids on sphingolipid synthesis, degradation, and tissue levels, suggest inhibition by corticosteroids of glucose uptake may be through effects of the steroid on sphingolipid metabolism.

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