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Dexamethasone and methylprednisolone do not inhibit neuritic outgrowth while inhibiting outgrowth of fibroblasts from spiral ganglion explants.

Authors
  • Furze, Alexis
  • Kralick, Deanna
  • Vakharia, Anand
  • Jaben, Korey
  • Graves, Reid
  • Adil, Eelam
  • Eshraghi, Adrien A
  • Balkany, Thomas J
  • Van de Water, Thomas R
Type
Published Article
Journal
Acta oto-laryngologica
Publication Date
Feb 01, 2008
Volume
128
Issue
2
Pages
122–127
Identifiers
PMID: 17851911
Source
Medline
License
Unknown

Abstract

Dexamethasone gave the best result of the three corticosteroids tested for inhibiting fibroblast outgrowth while not inhibiting neurite outgrowth from the ganglion micro-explants. Media containing hrBDNF (10 ng/ml) stimulated significantly greater neurite outgrowth than outgrowth from control explants (p < 0.001). Ganglion micro-explants treated with dexamethasone (0.02 mg/ml) and methylprednisolone (0.5 mg/ml) provided the greatest inhibition of fibroblast outgrowth compared with control explants (p < 0.001).

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