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Dexamethasone Downregulates Expressions of 14-3-3β and γ-Isoforms in Mice with Eosinophilic Meningitis Caused by Angiostrongylus cantonensis Infection.

Authors
  • Tsai, Hung-Chin1, 2
  • Chen, Yu-Hsin1
  • Yen, Chuan-Min2
  • Chung, Li-Yu2
  • Wann, Shue-Ren1
  • Lee, Susan Shin-Jung1
  • Chen, Yao-Shen1
  • 1 Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan and National Yang-Ming University, Taipei, Taiwan. , (Taiwan)
  • 2 Department of Parasitology and Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. , (Taiwan)
Type
Published Article
Journal
The Korean journal of parasitology
Publication Date
Jun 01, 2019
Volume
57
Issue
3
Pages
249–256
Identifiers
DOI: 10.3347/kjp.2019.57.3.249
PMID: 31284347
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Steroids are commonly used in patients with eosinophilic meningitis caused by A. cantonensis infections. The mechanism steroids act on eosinophilic meningitis remains unclear. In this mouse experiments, expressions of 14-3-3 isoform β and γ proteins significantly increased in the CSF 2-3 weeks after the infection, but not increasedin the dexamethasone-treated group. Expression of 14-3-3 β, γ, ε, and θ isoforms increased in brain meninges over the 3-week period after infection and decreased due to dexamethasone treatment. In conclusion, administration of dexamethasone in mice with eosinophilic meningitis decreased expressions of 14-3-3 isoform proteins in the CSF and in brain meninges.

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