Developments in component-based normalization for 3D PET.
- Authors
- Type
- Published Article
- Journal
- Physics in Medicine and Biology
- Publisher
- IOP Publishing
- Volume
- 44
- Issue
- 2
- Pages
- 571–594
- Source
- Badawi Lab
- License
- Unknown
Abstract
Normalization in positron emission tomography (PET) is the process of ensuring that all lines of response joining detectors in coincidence have the same effective sensitivity. In three-dimensional (3D) PET, normalization is complicated by the presence of a large proportion of scattered coincidences, and by the fact that cameras operating in 3D mode encounter a very wide range of count-rates. In this work a component-based normalization model is presented which separates the normalization of true and scattered coincidences and accounts for variations in normalization effects with count-rate. The effects of the individual components in the model on reconstructed images are investigated, and it is shown that only a subset of these components has a significant effect on reconstructed image quality.