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Developmental regulation of the growth plate.

Authors
  • Kronenberg, Henry M
Type
Published Article
Journal
Nature
Publication Date
May 15, 2003
Volume
423
Issue
6937
Pages
332–336
Identifiers
PMID: 12748651
Source
Medline
License
Unknown

Abstract

Vertebrates do not look like jellyfish because the bones of their skeletons are levers that allow movement and protect vital organs. Bones come in an enormous variety of shapes and sizes to accomplish these goals, but, with few exceptions, use one process--endochondral bone formation--to generate the skeleton. The past few years have seen an enormous increase in understanding of the signalling pathways and the transcription factors that control endochondral bone development.

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