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Developmental regulation of CYCA2s contributes to tissue-specific proliferation in Arabidopsis.

Authors
  • Vanneste, Steffen
  • Coppens, Frederik
  • Lee, Eunkyoung
  • Donner, Tyler J
  • Xie, Zidian
  • Van Isterdael, Gert
  • Dhondt, Stijn
  • De Winter, Freya
  • De Rybel, Bert
  • Vuylsteke, Marnik
  • De Veylder, Lieven
  • Friml, Jiří
  • Inzé, Dirk
  • Grotewold, Erich
  • Scarpella, Enrico
  • Sack, Fred
  • Beemster, Gerrit T S
  • Beeckman, Tom
Type
Published Article
Journal
The EMBO Journal
Publisher
EMBO
Publication Date
Aug 17, 2011
Volume
30
Issue
16
Pages
3430–3441
Identifiers
DOI: 10.1038/emboj.2011.240
PMID: 21772250
Source
Medline
License
Unknown

Abstract

In multicellular organisms, morphogenesis relies on a strict coordination in time and space of cell proliferation and differentiation. In contrast to animals, plant development displays continuous organ formation and adaptive growth responses during their lifespan relying on a tight coordination of cell proliferation. How developmental signals interact with the plant cell-cycle machinery is largely unknown. Here, we characterize plant A2-type cyclins, a small gene family of mitotic cyclins, and show how they contribute to the fine-tuning of local proliferation during plant development. Moreover, the timely repression of CYCA2;3 expression in newly formed guard cells is shown to require the stomatal transcription factors FOUR LIPS/MYB124 and MYB88, providing a direct link between developmental programming and cell-cycle exit in plants. Thus, transcriptional downregulation of CYCA2s represents a critical mechanism to coordinate proliferation during plant development.

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