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Developmental regulation of 5-HT1A receptor mRNA in the fetal limbic system: response to antenatal glucocorticoid.

Authors
  • Andrews, Marcus H1
  • Kostaki, Alice
  • Setiawan, Elaine
  • McCabe, Lucy
  • Matthews, Stephen G
  • 1 Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, rm 3240, 1 King's College Circle, Toronto, Ontario, Canada M5S1A8. [email protected] , (Canada)
Type
Published Article
Journal
Developmental Brain Research
Publisher
Elsevier
Publication Date
Mar 22, 2004
Volume
149
Issue
1
Pages
39–44
Identifiers
PMID: 15013627
Source
Medline
License
Unknown

Abstract

The developmental changes in 5-HT1A receptor mRNA expression associated with advancing gestational age were examined in the fetal guinea pig hippocampus and dentate gyrus (DG) by in situ hybridization. We found that 5-HT1A receptor mRNA was present in the hippocampal CA1 subfield and dentate gyrus (DG), and was significantly (P < 0.05) elevated in the DG during the period of rapid brain growth [gestational day (gd) 50; term = 70 days]. Glucocorticoids have been shown to alter 5-HT1A receptor mRNA expression in the adult, but nothing is known about their impact on the developing fetal brain. Expression of 5-HT1A receptor mRNA in the fetal hippocampus was measured following repeated maternal administration (gd40, 41, 50, 51, 60 and 61) of synthetic glucocorticoid (dexamethasone; 1 and 10 mg/kg). Levels of 5-HT1A receptor mRNA were significantly (P < 0.005) elevated in CA1 and DG following repeated exposure to high-dose glucocorticoid (10 mg/kg) in male, but not in female fetuses. Because fetal exposure to glucocorticoids programs hypothalamo-pituitary-adrenal (HPA) function, and hippocampal serotonin is known to influence glucocorticoid receptor (GR) expression, the glucocorticoid-mediated changes in 5-HT1A receptor mRNA may play a role in the programming of HPA function.

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