Developmental Potential and Plasticity of Olfactory Epithelium Stem Cells Revealed by Heterotopic Grafting in the Adult Brain

Qian Li; Tiziano Siri; Cedric Bressan; Yves de Koninck; Armen Saghatelyan

doi:10.1016/j.stemcr.2020.03.008

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Developmental Potential and Plasticity of Olfactory Epithelium Stem Cells Revealed by Heterotopic Grafting in the Adult Brain

Authors

Li, Qian¹
Siri, Tiziano¹
Bressan, Cedric¹
de Koninck, Yves^{1, 2}
Saghatelyan, Armen^{1, 2}

¹ CERVO Brain Research Center, Quebec City, QC G1J 2G3, Canada
² Department of Psychiatry and Neuroscience, Université Laval, Quebec City, QC G1K 7P4, Canada

Type

Published Article

Journal

Stem Cell Reports

Publisher

Elsevier

Publication Date

Apr 02, 2020

Volume

14

Issue

4

Pages

692–702

Identifiers

DOI: 10.1016/j.stemcr.2020.03.008

PMID: 32243847

PMCID: PMC7160358

Source

PubMed Central

Keywords

License

Unknown

Abstract

In this article, Saghatelyan and colleagues show that olfactory epithelium-derived neural stem cells adapt their developmental program in response to heterotopic neurogenic niche factors after grafting in vivo . They migrate and differentiate into ectopic brain region neurons that are indistinguishable in their morpho-functional properties from endogenous adult-born neurons.

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