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Developmental Potential and Plasticity of Olfactory Epithelium Stem Cells Revealed by Heterotopic Grafting in the Adult Brain

Authors
  • Li, Qian1
  • Siri, Tiziano1
  • Bressan, Cedric1
  • de Koninck, Yves1, 2
  • Saghatelyan, Armen1, 2
  • 1 CERVO Brain Research Center, Quebec City, QC G1J 2G3, Canada
  • 2 Department of Psychiatry and Neuroscience, Université Laval, Quebec City, QC G1K 7P4, Canada
Type
Published Article
Journal
Stem Cell Reports
Publisher
Elsevier
Publication Date
Apr 02, 2020
Volume
14
Issue
4
Pages
692–702
Identifiers
DOI: 10.1016/j.stemcr.2020.03.008
PMID: 32243847
PMCID: PMC7160358
Source
PubMed Central
Keywords
License
Unknown

Abstract

In this article, Saghatelyan and colleagues show that olfactory epithelium-derived neural stem cells adapt their developmental program in response to heterotopic neurogenic niche factors after grafting in vivo . They migrate and differentiate into ectopic brain region neurons that are indistinguishable in their morpho-functional properties from endogenous adult-born neurons.

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