Affordable Access

Developmental genetic malformations of the cerebral cortex.

Authors
Type
Published Article
Journal
Current neurology and neuroscience reports
Publication Date
Volume
3
Issue
5
Pages
433–441
Identifiers
PMID: 12914687
Source
Medline
License
Unknown

Abstract

Cortical malformations give rise to severe clinical manifestations such as epilepsy and mental retardation, but sometimes to more subtle problems like dyslexia. From a clinical standpoint, such structural abnormalities are diagnosed by radiographic and histologic findings, with disease classifications often based on these observations. Using this categorization, many of the responsible genes have been determined and now provide a means of understanding the molecular basis of the neurologic disorders. This review discusses the known genetic developmental syndromes in the context of the observed cortical malformations, the expression and function of the responsible genes, and their potential roles during the various stages of central nervous system development.

Statistics

Seen <100 times