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The developmental expression profile of PAX2 in the murine prostate.

Authors
  • Chen, Qian
  • DeGraff, David J
  • Sikes, Robert A
Type
Published Article
Journal
The Prostate
Publisher
Wiley (John Wiley & Sons)
Publication Date
May 01, 2010
Volume
70
Issue
6
Pages
654–665
Identifiers
DOI: 10.1002/pros.21099
PMID: 20017165
Source
Medline
License
Unknown

Abstract

The expression profile of PAX2 indicates that it may regulate early, androgen-independent stages of murine prostate development, particularly for dorsally derived prostate glands. PAX2 expression appears to be associated with a dorsally localized epithelial cell population that is castration insensitive and retains proliferative and differentiative potential. Such a population of cells may represent a subset of stem-like cells having some characteristics in common with castrate-resistant prostate cancer cells.

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