Development of in vivo bioequivalence methodology for dermatologic corticosteroids based on pharmacodynamic modeling.
- Published Article
Clinical pharmacology and therapeutics
- Publication Date
Oct 01, 1999
Acceptable model fits to all individual subject dose-response data were not achieved for any dermatologic corticosteroid product. However, population dose-responses were adequately described by the Emax model. On the basis of these data, the optimal dose duration used for comparison of multisource dermatologic corticosteroid products is recommended to be equal to the ED50 based on population modeling of pilot dose-response study data.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/10546918