Affordable Access

deepdyve-link
Publisher Website

Development of a three-zone simulated moving bed process based on partial-discard strategy for continuous separation of valine from isoleucine with high purity, high yield, and high product concentration

Authors
  • Park, Chanhun
  • Nam, Hee-Geun
  • Hwang, Hee-Jeong
  • Kim, Jin-Hyun
  • Mun, Sungyong1, 2, 3
  • 1 Department of Chemical Engineering
  • 2 Department of Fuel Cells and Hydrogen Technology
  • 3 Department of Chemical Engineering, Kongju National University
Type
Published Article
Journal
Process Biochemistry
Publisher
Elsevier
Publication Date
Jan 01, 2013
Accepted Date
Oct 26, 2013
Volume
49
Issue
2
Pages
324–334
Identifiers
DOI: 10.1016/j.procbio.2013.10.021
Source
Elsevier
Keywords
License
Unknown

Abstract

The issue of separating valine from isoleucine has been a major concern in the biotechnological process for production of valine. To address this issue, an optimal three-zone simulated moving bed (SMB) process for continuous separation of valine was developed in this study. It was first found that an Amberchrom-CG161C resin was highly suitable for the adsorbent of such SMB process. The adsorption isotherm and mass-transfer parameters of valine and isoleucine on the Amberchrom-CG161C adsorbent were then determined through multiple frontal experiments. The determined parameters were used in the next stage of optimizing the SMB for valine separation, which was performed on the basis of genetic algorithm. For the optimized SMB process, a partial-discard strategy was applied to the raffinate port in order to make a further improvement in the valine product concentration. Finally, the optimized SMB based on the partial-discard strategy was tested experimentally using the self-assembled SMB equipment. The experimental results showed that the developed process in this study was highly effective in continuous separation of valine from isoleucine while ensuring the attainment of high product concentration. The experimental data for the SMB effluent histories and the SMB column profiles were also in close agreement with the model predictions.

Report this publication

Statistics

Seen <100 times