Affordable Access

Access to the full text

Development and Performance of Bioactive Compounds-Loaded Cellulose/Collagen/Polyurethane Materials

Authors
  • Spiridon, Iuliana1
  • Anghel, Narcis1
  • Dinu, Maria Valentina1
  • Vlad, Stelian1
  • Bele, Adrian1
  • Ciubotaru, Bianca Iulia2
  • Verestiuc, Liliana2
  • Pamfil, Daniela1
  • 1 (D.P.)
  • 2 (L.V.)
Type
Published Article
Journal
Polymers
Publisher
MDPI AG
Publication Date
May 23, 2020
Volume
12
Issue
5
Identifiers
DOI: 10.3390/polym12051191
PMID: 32456132
PMCID: PMC7284988
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Green

Abstract

Here we present a new biomaterial based on cellulose, collagen and polyurethane, obtained by dissolving in butyl imidazole chloride. This material served as a matrix for the incorporation of tannin and lipoic acid, as well as bioactive substances with antioxidant properties. The introduction of these bioactive principles into the base matrix led to an increase of the compressive strength in the range 105–139 kPa. An increase of 29.85% of the mucoadhesiveness of the film containing tannin, as compared to the reference, prolongs the bioavailability of the active substance; a fact also demonstrated by the controlled release studies. The presence of bioactive principles, as well as tannins and lipoic acid, gives biomaterials an antioxidant capacity on average 40%–50% higher compared to the base matrix. The results of the tests of the mechanical resistance, mucoadhesiveness, bioadhesiveness, water absorption and antioxidant capacity of active principles recommend these biomaterials for the manufacture of cosmetic masks or patches.

Report this publication

Statistics

Seen <100 times